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PEOPLE TALK PrEP

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KARAMO

KARAMO:

Hey friends! Welcome to People Talk PrEP. I’m your host Karamo, and I sat down with a few folks to talk about sexual health and PrEP. Take a look.

KARAMO:

I’m joined by some amazing people from around the country. But before we start, I want you all to introduce yourselves. So, ladies first.

ANGELIQUE:

I’m Angelique.

KARAMO:

Yes.

BEN:

I’m Ben.

KARAMO:

Nice.

STEPHON:

Stephon.

KARAMO:

Stephon!

ALEX:

And Alex.

KARAMO:

Nice to meet you all.

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All participants were compensated by ViiV Healthcare.

STEPHON:

Nice to meet you too.

KARAMO:

Thank you! Um...alright so just to break the ice a little bit, I want to know – because we’re talking about sex, you know what I mean? What makes you feel sexy?

ALEX:

Like confidence, like in myself. I’m comfortable in my body, like, I’m comfortable in what I’m offering to my partner. I try my hardest to make the other person enjoy themselves.

KARAMO:

Yeah.

ANGELIQUE:

Communication is sexy.

KARAMO:

Yes, it is.

ANGELIQUE:

Like, if you can use your words and you know how to talk to me and tell me, like what you like, what you want to do, what you want me to do, I’m just like ah, okay!

KARAMO:

Are you sex positive with your friends?

STEPHON:

I didn’t come out of the closet until I turned 20. And even then, it was still conservative. I didn’t talk about sex to other people. I didn’t start talking about sex until I was just, like, let’s have a honest conversation with people. You know, what’s your status? What do you like to do? The more you do it the more comfortable you are with doing it.

KARAMO:

You better preach. (laughing) You better preach. Yes! How do you become so sex positive?

BEN:

I grew up in the Midwest, in a pretty conservative town. It wasn’t until, like, I started coming out that I realized like, it’s important for me to be who I am and to share my opinions on things. Um, and I feel like sex, especially, is such a taboo topic that people don’t talk about. Sex is like a journey. It’s important to, like – both you and your partner have fun with it.

KARAMO:

If you keep practicing having those conversations, it becomes easier, and becomes just a part of who you are. I think it’s great that we just start off talking about sex. Because I think sometimes when we get into the PrEP conversation, we - it gets too clinical. It gets too, like, scary. And I think that taking away some of that fear and that stigma…is important. And being sex positive is always great. Let’s talk a bit about APRETUDE.

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Karamo back in :26

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HIV is the virus that causes AIDS. 

Talk to your healthcare provider to see if APRETUDE may be right for you.

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[APRETUDE logo]

ANNOUNCER:

APRETUDE is a prescription medicine used for HIV-1 PrEP to reduce the risk of getting HIV-1 infection in adults and adolescents who weigh at least 77 pounds (at least 35 kilograms). Before receiving APRETUDE to reduce your risk of getting HIV-1, you must be HIV-1 negative.

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Karamo back in :08

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Watch the complete video for more Important Safety Information.

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[APRETUDE logo]

ANNOUNCER:

Do not receive APRETUDE unless you are tested and confirmed to be negative. Watch the complete video for more safety information.

KARAMO:

I have a question for you all. So, by a show of hands, who’s on APRETUDE and who’s on a daily PrEP?

ANGELIQUE:

Daily PrEP.

KARAMO:

Daily PrEP.

BEN:

APRETUDE.

STEPHON:

APRETUDE.

ALEX:

Daily PrEP.

KARAMO:

Nice, and so what are the challenges that you’ve experienced while taking daily PrEP?

ANGELIQUE:

Um, it’s definitely the run-ins with forgetting, um, and then having to do the prescription refills and making sure you take it daily. Sometimes, I can’t lie, I skip a day or two.

KARAMO:

Yeah.

ALEX:

At the beginning, I would just take like a pill from the bottle and like just pop it, but then, I found out that like, I’m kind of forgetful sometimes, so like, I’ll forget it in the morning and then I’ll double question myself, if - did I take it already or did I not and then I found myself like dumping the whole bottle and counting the pills. 

KARAMO:

And counting? (laughs) So, for you, Stephon, why was long-acting PrEP, like, appealing?

STEPHON:

I don’t have to set an alarm anymore, and I just set my appointment for every two months.

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APRETUDE is given as few as 6 times a year every other month by a healthcare provider after initiation injections have been given 1 month apart for 2 consecutive months.

STEPHON:

I get shot in the butt, and then…(laughing) set it for two months later.

KARAMO:

When I learned about APRETUDE…I thought that there’s a long-acting PrEP that you can take six times a year? Once every other month?

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Stay under the care of a healthcare provider while receiving APRETUDE.

KARAMO:

To know that there’s this first option of this ever, this long-acting PrEP. So for you being on it, um, and for you being on it, I guess I’ll start with you now, Ben. What has it been like being on APRETUDE?

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You must receive APRETUDE as scheduled. You have a Flexible Appointment Window from 7 days before to 7 days after your Target Appointment Date.

BEN:

For me at least, it’s been a very easy, uh, to set up the appointments, because not only do you try and set it for two months out, but there’s a little bit of a buffer window of a week on either end of that. 

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If you will miss a scheduled injection of APRETUDE by more than 7 days, call your healthcare provider right away.

BEN:

You go to your doctor’s appointment six times a year,…

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Your healthcare provider will test you for HIV-1 to confirm you are negative prior to each injection.

BEN:

…you get your blood work, you get the, the shot at the same time.

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You must be HIV-1 negative to start and stay on APRETUDE. Individual results may vary.

BEN:

From my personal experience, I experienced injection-site pain for a couple of days afterwards.

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In clinical trials, many patients experienced injection-site reactions (pain, tenderness, hardened mass or lump, swelling, bruising, redness, itching, warmth, loss of sensation at the injection site, abscess, and discoloration) after receiving APRETUDE.

BEN:

I still could hike every day. I still could go running, I can still go to the gym. It fit in my lifestyle well, um, it, it was, um, discreet…

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Talk to your doctor about the activities you can do while on APRETUDE.

BEN:

…not that I really ever had an issue with, like, people going through my medicine or anything like that, um, but for people that that is a concern, they’re - you, it all fits into your doctor’s appointments.

ALEX:

As a person that takes the daily PrEP, one of the most appealing things about the injectable PrEP is that you have more control over your sexual health, because you have to go more often to the doctor...

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PrEP doesn’t prevent other sexually transmitted infections (STIs). To help you stay protected, always practice safer sex and use a condom.

ALEX:

…and you’re more aware of your sexual, like, status.

KARAMO:

I think it’s just great that this is the first and only long-acting PrEP that you take it every other month basically. And that type of knowledge just makes me so happy to hear! How does it make you all feel that, knowing that there is an option like this out there?

ANGELIQUE:

Nice.

ALEX:

Super exciting.

KARAMO:

Yeah.

STEPHON:

Yeah, I, I was just like, ooh, I forgot to take this pill. What if my test results come back the way I don’t want it to? I would, like, freak out and then they’ll tell me, oh, okay, you’re, you’re HIV negative. I would be like oh, okay, thank you! Ha. But when I got on APRETUDE, I didn’t miss a day.

KARAMO:

So how do you feel about the representation and why you’re here?

ANGELIQUE:

Um, I feel great. I really wanted to be a part of the change cause oftentimes we don’t get that visibility of black trans women, especially at the forefront of prevention things, so to have that would be great.

KARAMO:

Kudos, sister!

ANGELIQUE:

Of course.

KARAMO:

Um, um, so what appeals to you about long-acting PrEP and travel? Because I know you’re always on the road as a model, a designer. What is appealing to you?

ANGELIQUE:

I’m taking the daily pill like 365 days a year,…

KARAMO:

Okay. 

ANGELIQUE:

…so to have that chance to take it down would be great.

KARAMO:

You being here is so important, so thank you for being here, and being that voice.

ANGELIQUE:

Starting that conversation.

KARAMO:

Yeah, starting that conversation, but also you’re right! Like, going from 365 days of taking a pill, to then 6 times a year. I mean that is dramatic,…

ANGELIQUE:

Honestly.

KARAMO:

…which is really great. Well, listen, I just love that we are having this conversation. Again, we’re all from different walks of life, but what I love about APRETUDE is that this clinical trial, this study, is probably one of the most diverse ever. The fact that it’s like, in-included not only cisgender men, it’s also included trans women and cisgender women. And I think knowing that it’s been tested among thousands and thousands of people, which is so great to reassure that this is something that helps protect, and that is available, which is so, so awesome. I think this conversation about sex, about long-acting PrEP, and about just coming together and communicating and the confidence that comes with that was so important. So thank you for being here.

STEPHON:

Thank you for having us.

KARAMO:

Yes! Give me some hugs before y’all get outta here.

ANGELIQUE:

Help me up. 

KARAMO:

I gotchu! Mwah! Mwah! Aw, I’m going to miss y’all. Oh, me and you must never part. I know. You will.

KARAMO:

What an inspiring conversation. Did y’all have fun? ‘Cause I did.

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PrEP doesn't prevent other STIs. To help you stay protected, always practice safer sex and use a condom.

KARAMO:

And I love the fact that we learned that safe sex is not about fear. It’s about confidence. So continue to have that confidence and communicate with the people in your lives. And make sure to also invite people who are normally not in the conversation into the conversation. Because when we start talking, that’s when we see us living healthier and better lives together. Listen, I want to give a big, special thank you to Angelique, Alejandro, Ben, and Stephon for coming through today, dropping that knowledge on us, and for being so open and vulnerable. Listen, until next time, take care.

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Watch the complete video for more Important Safety Information.

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[APRETUDE logo]

ANNOUNCER AND ONSCREEN:

What is APRETUDE?

APRETUDE is a prescription medicine used for HIV-1 PrEP to reduce the risk of getting HIV-1 infection in adults and adolescents who weigh at least 77 pounds (at least 35 kg). 

IMPORTANT SAFETY INFORMATION

What is the most important thing I should know about APRETUDE?

Important information for people who receive APRETUDE to help reduce their risk of getting human immunodeficiency virus-1 (HIV-1) infection, also called pre-exposure prophylaxis or “PrEP”:

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IMPORTANT SAFETY INFORMATION (cont’d)

What is the most important thing I should know about APRETUDE? (cont’d)

ANNOUNCER AND ONSCREEN:

Before receiving APRETUDE to reduce your risk of getting HIV-1, you must be HIV-1 negative to start APRETUDE. Do not receive APRETUDE unless you are tested and confirmed to be HIV-1 negative.

• Some HIV-1 tests can miss HIV-1 infection in a person who has recently become infected. Tell your healthcare provider if you had a flu-like illness within the last month before starting or at any time while receiving APRETUDE. Symptoms of new HIV-1 infection include: tiredness; joint or muscle aches; sore throat; rash; enlarged lymph nodes in the neck or groin; fever; headache; vomiting or diarrhea; or night sweats

While you are receiving APRETUDE for HIV-1 PrEP:

• APRETUDE does not prevent other sexually transmitted infections (STIs). Practice safer sex by using a latex or polyurethane condom to reduce the risk of getting STIs

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IMPORTANT SAFETY INFORMATION (cont’d)

What is the most important thing I should know about APRETUDE? (cont’d)

While you are receiving APRETUDE for HIV-1 PrEP: (cont'd)

ANNOUNCER AND ONSCREEN:

• You must stay HIV-1 negative to keep receiving APRETUDE for HIV-1 PrEP
  • Know your HIV-1 status and the HIV-1 status of your partners. If you think you were exposed to HIV-1, tell your healthcare provider right away
  • Your risk of getting HIV-1 is lower if your partners with HIV-1 are taking effective treatment
  • Get tested for HIV-1 with each APRETUDE injection or when your healthcare provider tells you. You should not miss any HIV-1 tests. If you become HIV-1 infected and continue receiving APRETUDE because you do not know you are HIV-1 infected, the HIV-1 infection may become harder to treat
  • Get tested for other STIs. These infections make it easier for HIV-1 to infect you
  • Talk to your healthcare provider about ways to reduce your HIV-1 risk
  • Do not miss any injections of APRETUDE. Missing injections increases your risk of getting HIV-1 infection

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IMPORTANT SAFETY INFORMATION (cont’d)

ANNOUNCER AND ONSCREEN:

Who should not receive APRETUDE?

Do not receive APRETUDE if you:

• already have HIV-1 or do not know your HIV-1 status. If you are HIV-1 positive, you need to take other medicines to treat HIV-1. APRETUDE can only help reduce your risk of getting HIV-1 infection before you are infected. If you have HIV-1 and receive only APRETUDE, over time, your HIV-1 may become harder to treat 
• are allergic to cabotegravir 
• are taking certain medicines: carbamazepine; oxcarbazepine; phenobarbital; phenytoin; rifampin; or rifapentine

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IMPORTANT SAFETY INFORMATION (cont’d)

ANNOUNCER AND ONSCREEN:

What are the possible side effects of APRETUDE?

APRETUDE may cause serious side effects:

• Allergic reactions. Call your healthcare provider right away if you develop a rash with APRETUDE. Stop receiving APRETUDE and get medical help right away if you develop a rash with any of the following signs or symptoms: fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue 

• Liver problems. Liver problems have happened in people with or without a history of liver problems or other risk factors. Call your healthcare provider right away if you have any of the following symptoms: your skin or the white part of your eyes turns yellow; dark or “tea-colored” urine; light-colored stools; nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of your stomach area; or itching

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IMPORTANT SAFETY INFORMATION (cont’d)

What are the possible side effects of APRETUDE (cont’d)?

APRETUDE may cause serious side effects (cont’d):

ANNOUNCER AND ONSCREEN:

• Depression or mood changes. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; have thoughts of hurting yourself (suicide) or have tried to hurt yourself

The most common side effects of APRETUDE include:

• Pain, tenderness, hardened mass or lump, swelling, bruising, redness, itching, warmth, loss of sensation at the injection site, abscess, and discoloration; diarrhea; headache; fever; tiredness; sleep problems; nausea; dizziness; passing gas; stomach pain; vomiting; muscle pain; rash; loss of appetite; drowsiness; back pain; or upper respiratory infection 
• These are not all the possible side effects of APRETUDE. Call your healthcare provider for medical advice about side effects

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IMPORTANT SAFETY INFORMATION (cont’d)

ANNOUNCER AND ONSCREEN:

Before receiving APRETUDE, tell your healthcare provider about all your medical conditions, including if you:

• have ever had a skin rash or an allergic reaction to medicines that contain cabotegravir 
• have or have had liver problems 
• have ever had mental health problems 
• are pregnant or plan to become pregnant. It is not known if APRETUDE will harm your unborn baby. APRETUDE can remain in your body for up to 12 months or longer after the last injection. Tell your healthcare provider if you become pregnant while receiving APRETUDE 
• are breastfeeding or plan to breastfeed. It is not known if APRETUDE can pass to your baby in your breast milk. Talk with your healthcare provider about the best way to feed your baby while receiving APRETUDE

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IMPORTANT SAFETY INFORMATION (cont’d)

Before receiving APRETUDE, tell your healthcare provider about all your medical conditions, including if you (cont’d):

ANNOUNCER AND ONSCREEN:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

• Some medicines may interact with APRETUDE. Keep a list of your medicines and show it to your healthcare provider and pharmacist. Do not start a new medicine without telling your healthcare provider

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IMPORTANT SAFETY INFORMATION (cont’d)

ANNOUNCER AND ONSCREEN:

How will I receive APRETUDE?

• APRETUDE is initially given as an injection into the muscle of your buttock 1 time every month for the first 2 months, then as an injection 1 time every 2 months 
• Before receiving your first APRETUDE injection, your healthcare provider may have you take 1 oral cabotegravir tablet 1 time a day for 1 month (at least 28 days) to assess how well you tolerate cabotegravir 
• APRETUDE is a long-acting medicine and may stay in your body for 12 months or longer after your last injection 
• Stay under the care of a healthcare provider while receiving APRETUDE. It is important that you receive APRETUDE as scheduled 
• If you miss or plan to miss a scheduled injection of APRETUDE by more than 7 days, call your healthcare provider right away to discuss your PrEP options 
• If you stop receiving APRETUDE, talk to your healthcare provider about other options to reduce the risk of getting HIV-1 infection

ANNOUNCER AND ONSCREEN:

Please read the Patient Information for APRETUDE on this webpage, including an Important Warning, and discuss it with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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PEOPLE TALK PrEP

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Trademarks are owned by or licensed to the ViiV Healthcare group of companies. 

©2022 ViiV Healthcare or licensor.

CBTVID220017 August 2022 

Produced in USA.